Why the study?
A comparative analysis of the immunogenicity and safety of different poliovirus immunization schedules in Chinese infants was needed to guide efficient strategies for poliomyelitis eradication.
Do different poliovirus immunization schedules affect immunogenicity and safety in Chinese infants?
Population
2,400 infants aged 60-90 days from two clinical trials in China
Comparison
Different poliovirus immunization schedules using tOPV, bOPV, sIPV, and cIPV
Design
Post hoc analysis of two clinical trials
Follow-up
28 days after the last of three doses
Authors
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One-dose IPV sequential schedules may inadequately protect against type II poliovirus; leaves open optimal IPV-bOPV sequencing pending confirmatory trials.
Do different poliovirus immunization schedules affect immunogenicity and safety in Chinese infants?
Two or more doses of IPV should be administered before vaccination with bOPV in a sequential schedule to improve immunity against type II poliovirus.
Zhao et al. (2021) studied this question.
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