Why the study?
Does a sequential schedule of IPV followed by OPV provide noninferior immunogenicity compared to OPV alone in healthy infants?
Population
Healthy Chinese infants
Comparison
Sequential schedules of inactivated polio… vs OPV-only schedule at 2, 3, and 4 months of age
Design
RCT
Follow-up
14-months post-Dose 3
Authors
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Supports sequential IPV-OPV schedules in healthy infants; confirms noninferior immunogenicity to OPV alone and extends schedule flexibility.
Does a sequential schedule of IPV followed by OPV provide noninferior immunogenicity compared to OPV alone in healthy infants?
A primary series of 1 or 2 IPV doses followed by OPV doses is immunogenic and noninferior to an OPV-only schedule in healthy infants.
Li et al. (2015) studied this question.
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