Why the study?
The ability of oral poliovirus vaccine to regain replication fitness and establish new epidemics represents a significant risk of polio re-emergence should immunization cease.
Comparison
nOPV2 strain vs original Sabin2 strain
Authors
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Supports next steps in polio vaccine development; leaves open clinical translation from animal models.
The engineering of the nOPV2 vaccine strain improves genetic stability and reduces the risk of virulence reversion compared to the original Sabin2 strain, potentially aiding in complete poliovirus eradication.
Yeh et al. (2020) studied this question.
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