Population
Poliovirus strains (type 1, 2, and 3)
Comparison
Introduction of four mutations in the 5'… vs Present Sabin vaccine strains
Design
Preclinical
Authors
Loading...
Type 1/2 phenotypic reversion in animal models cautions live-attenuated poliovirus vaccine design; leaves open serotype-specific strategies for human testing.
Rational design of genetically stable live-attenuated poliovirus vaccines showed success for type 3 but significant phenotypic reversion for types 1 and 2, highlighting limitations in this approach.
Macadam et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: