Key result
Novel S19 poliovirus strains were hyperattenuated with no measurable neurovirulence in transgenic mice, failed to infect primates orally, and yielded immunogenic virus suitable for safe IPV production.
Population
Preclinical models including cell cultures, transgenic mice carrying the human receptor for poliovirus, and…
Comparison
Genetically modified poliovirus strains designed… vs Unmodified Sabin vaccine strains and wild-type…
Design
Preclinical
Follow-up
up to 49 days (for primate infectivity model)
Authors
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May enable safer IPV production post-eradication; leaves open human translation from animal data.
Rationally designed, hyperattenuated poliovirus strains offer a safer alternative for the production of inactivated polio vaccines in the post-eradication era.
Knowlson et al. (2015) studied Poliomyelitis. S19 genetically modified poliovirus strains vs. Wild type and Sabin poliovirus strains was evaluated on Neurovirulence (PD50 in transgenic mice). Novel S19 poliovirus strains were hyperattenuated with no measurable neurovirulence in transgenic mice, failed to infect primates orally, and yielded immunogenic virus suitable for safe IPV production.
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