Key result
Oral poliovirus vaccine (OPV) is effective but its genetic instability leads to an estimated 250-500 cases of vaccine-associated paralytic polio globally per year.
Why the study?
The genetic instability of oral poliovirus vaccine strains can reverse attenuation, causing vaccine-associated paralytic polio and posing ongoing challenges to global eradication.
The genetic instability of the oral poliovirus vaccine leads to vaccine-associated paralytic polio, posing a significant challenge to global polio eradication efforts.
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May warrant preferential inactivated polio vaccine use in low-risk settings; leaves open strategies to mitigate vaccine-derived poliovirus circulation.
Cochi et al. (2020) conducted a review in Poliomyelitis and vaccine-associated paralytic polio (VAPP). Oral poliovirus vaccine (OPV) was evaluated. Oral poliovirus vaccine (OPV) is effective but its genetic instability leads to an estimated 250-500 cases of vaccine-associated paralytic polio globally per year.
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