Key result
Continued use of the oral polio vaccine has resulted in circulating vaccine-derived polioviruses causing about eight times more polio cases than wild poliovirus between 2008 and 2024.
Why the study?
Prolonged reliance on oral polio vaccine has impeded global polio eradication due to persistent safety challenges, including vaccine-associated paralytic polio and vaccine-derived polioviruses.
Does replacing oral polio vaccine with inactivated poliovirus vaccine improve safety and facilitate global polio eradication?
Comparison
Inactivated poliovirus vaccine vs oral polio vaccine
Authors
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May warrant OPV phase-out in eradication programs; leaves open optimal IPV transition strategies.
Does replacing oral polio vaccine with inactivated poliovirus vaccine improve safety and facilitate global polio eradication?
The paper argues for the global replacement of the oral polio vaccine with the inactivated poliovirus vaccine to eliminate vaccine-derived polio and achieve global eradication.
John et al. (2025) conducted an editorial in Poliomyelitis. Oral Polio Vaccine (OPV) vs. Inactivated Poliovirus Vaccine (IPV) was evaluated. Continued use of the oral polio vaccine has resulted in circulating vaccine-derived polioviruses causing about eight times more polio cases than wild poliovirus between 2008 and 2024.
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