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May 1, 1984Clinical Infectious Diseases

Live Attenuated Oral Poliovirus Vaccine

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Population

General population receiving live oral poliovirus vaccines

Design

Review

Authors

JMJoseph L. MelnickStatens Serum Institut

Discussion

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Implication

Supports continued OPV deployment in eradication programs; extends historical observations but leaves open optimal endgame strategies.

Structured PICO

P
Population
General population receiving live oral poliovirus vaccines
I
Intervention
Live attenuated oral poliovirus vaccine (OPV)
O
Outcome
Decrease in the number of paralytic cases

This review highlights the historical development, safety, and dramatic efficacy of the live attenuated oral poliovirus vaccine in reducing paralytic polio cases globally.

Cite This Study

Joseph L. Melnick (1984) studied this question.

synapsesocial.com/papers/6a919a59ae2c4ed52ef13bf0https://doi.org/10.1093/clinids/6.supplement_2.s323
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Problems Associated with the Use of Live Poliovirus Vaccine1960 · 35 citations
  2. 2Effect of pH on Thermal Stabilization of Oral Poliovirus Vaccine by Magnesium Chloride1963 · 21 citations
  3. 3Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.1981 · 556 citations
  4. 4Sequence of picornavirus RNAs containing a radioiodinated 5'-linked peptide reveals a conserved 5' sequence.1980 · 32 citations
  5. 5Regulation of Simian Virus 40 Transcription: Sensitive Analysis of the RNA Species Present Early in Infections by Virus or Viral DNA1979 · 621 citations