Why the study?
Does a combined schedule of IPV followed by OPV provide excellent immunity and reduce vaccine-associated paralytic polio?
Population
General population receiving poliovirus vaccination
Design
Review
Authors
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May support IPV-OPV schedules to minimize VAPP; leaves open randomized confirmation in current epidemiology.
Does a combined schedule of IPV followed by OPV provide excellent immunity and reduce vaccine-associated paralytic polio?
A combined schedule of enhanced potency IPV followed by OPV may reduce vaccine-associated paralytic polio while retaining good mucosal protection.
Howard Faden (1993) studied this question.
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