Key result
Oral live poliovirus vaccine safety and immunogenicity remain debated amid concerns over virulence reversion.
Why the study?
Uncertainty existed about the safety and immunogenicity of oral live poliovirus vaccines for recipients and contacts, and their suitability for poliomyelitis elimination.
Does the oral, live poliovirus vaccine safely immunize and eliminate poliomyelitis in humans?
Population
Millions of human beings who received oral poliovirus vaccines in 1958 and 1959 worldwide
Design
Review of experimental and trial data on oral poliovirus vaccines
Authors
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Concerns over reversion to virulence advise caution with oral poliovirus vaccine in eradication efforts; leaves open definitive long-term safety assessment.
Does the oral, live poliovirus vaccine safely immunize and eliminate poliomyelitis in humans?
The paper reviews the safety and immunogenicity of the oral live poliovirus vaccine for the elimination of poliomyelitis.
Albert B. Sabin (1960) conducted a review in Poliomyelitis. Oral, live poliovirus vaccine was evaluated. The safety and immunogenicity of the oral, live poliovirus vaccine for the elimination of poliomyelitis are under discussion, alongside concerns about potential reversion to virulence.
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