Key result
Live oral attenuated poliovirus vaccines show no benefit over inactivated vaccines and may hinder definitive evaluation.
Why the study?
Does live oral attenuated poliovirus vaccine improve outcomes compared to inactivated vaccine?
Does live oral attenuated poliovirus vaccine improve outcomes compared to inactivated vaccine?
The author cautions against mass immunization with live oral poliovirus vaccines due to unproven superiority and narrow safety margins compared to inactivated vaccines.
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Cautions against mass live oral polio vaccine deployment; leaves open rigorous comparative evaluation versus inactivated vaccines.
David Bodian (1961) conducted an editorial in Poliomyelitis. Live oral attenuated poliovirus vaccines vs. Inactivated vaccines was evaluated. Live oral attenuated poliovirus vaccines have not demonstrated superiority over inactivated vaccines, and their mass implementation may hinder definitive evaluation of either vaccine.
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