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January 1, 1960Public Health Reports (1896-1970)Open Access

Oral Poliovirus Vaccine: Statement

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Population

American population (general public for polio vaccination)

Design

Guideline

Authors

LBLeroy E. BurneyOklahoma State Department of Health

Discussion

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Implication

Enables U.S. licensing and commercial supply of live oral polio vaccine by 1961; extends international conference data into national manufacturing standards.

Structured PICO

P
Population
American population (general public for polio vaccination)
I
Intervention
Live oral poliovirus vaccine (Sabin type 1, 2, and 3 strains)

The 1960 Surgeon General statement established the regulatory and manufacturing framework for introducing the live oral poliovirus vaccine in the United States.

Limitations

  • Need for definitive information on viremia in man
  • Sabin type 3 strain has less than optimum immunogenic capacity and shows a tendency to change its neurovirulence characteristics after passage in man

Cite This Study

Leroy E. Burney (1960) studied Poliomyelitis. Live oral poliovirus vaccine (Sabin strains) was evaluated. The Public Health Service Committee recommended the use of Sabin type 1 and type 2 strains for live oral poliovirus vaccine manufacture due to their favorable laboratory and field characteristics.

synapsesocial.com/papers/6aa2269357affa4c5d46f320https://doi.org/10.2307/4590949
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poliomyelitis Immunization1961 · 21 citations
  2. 2Present Position of Immunization Against Poliomyelitis with Live Virus Vaccines1959 · 199 citations
  3. 3Status of Vaccination against Poliomyelitis, with Particular Reference to Oral Vaccination1961 · 10 citations
  4. 4Poliomyelitis Vaccination with Live Poliovirus1961 · 9 citations
  5. 5Oral, Live Poliovirus Vaccine for Elimination of Poliomyelitis1960 · 12 citations