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Review the historical development of live poliovirus vaccines and report on their clinical and scientific status as of December 1960.

Status of Vaccination against Poliomyelitis, with Particular Reference to Oral Vaccination

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Review the historical development of live poliovirus vaccines and report on their clinical and scientific status as of December 1960.
Historical narrative review evaluating early poliovirus research and vaccination strategies following the discovery of the virus in 1909.
Synthesis of experimental laboratory investigations, including monkey trials involving killed and live poliovirus formulations beginning in 1910.
Efforts to engineer effective killed and live viral vaccines began almost immediately after the isolation of poliovirus in 1909.
Early preclinical investigations established the feasibility of live virus immunization, leading to modern oral vaccine formulations evaluated through 1960.

Intervention

Live poliovirus vaccines (oral vaccination)

A historical review of the development and status of live poliovirus vaccines as of December 1960.

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Provides 1960-era context on live poliovirus vaccines; leaves open their status in current global programs.

John R. Paul (1961) studied this question.

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