Why the study?
Does two doses of trivalent oral poliovirus vaccine maintain detectable antibodies in children previously immunized with formalin-inactivated vaccine?
Population
200 children previously immunized with formalin-inactivated vaccine
Design
Cohort
Follow-up
8 years
Authors
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Supports durable seropositivity after sequential IPV-OPV; hypothesis-generating and leaves open need for prospective confirmation in modern schedules.
Does two doses of trivalent oral poliovirus vaccine maintain detectable antibodies in children previously immunized with formalin-inactivated vaccine?
Trivalent oral poliovirus vaccine maintains high rates of neutralizing antibodies for years after immunization.
Rousseau et al. (1973) studied this question.