What question did this study set out to answer?

To evaluate the long-term persistence of neutralizing antibodies against poliovirus types 1, 2, and 3 in individuals who received four or five doses of oral polio vaccine up to 19 years previously.

March 1, 2007Viral Immunology

Long-Lasting Poliovirus-Neutralizing Antibodies among Argentinean Population Immunized with Four Or Five Oral Polio Vaccine Doses 1 Month to 19 Years Previously

View Full Paper

Ask AI

Bookmark

Why the study?

Does the oral polio vaccine (OPV) provide long-lasting poliovirus-neutralizing antibodies in an immunized population?

Population

297 individuals residing in Argentina who had completed the vaccination cycle with four or five oral polio…

Design

Cross-sectional

Follow-up

1 month to 19 years post-vaccination

Authors

SNSilvia NatesUniversidad Nacional de Córdoba LMLaura C. Martı́nezUniversity of the Llanos PBPatricia A. BarrilCentro Científico Tecnológico - Tucumán

Discussion

Member takes

Implication

May warrant serostatus monitoring beyond 6 years post-OPV; leaves open optimal adult booster timing and population protection.

Key Points

To evaluate the long-term persistence of neutralizing antibodies against poliovirus types 1, 2, and 3 in individuals who received four or five doses of oral polio vaccine up to 19 years previously.
Evaluated poliovirus-neutralizing antibody persistence in 297 individuals residing in Argentina who completed a schedule of four or five oral polio vaccine (OPV) doses 1 month to 19 years before the study.
Measured seropositivity rates and geometric mean titers across poliovirus types 1, 2, and 3 over intervals spanning up to 19 years postvaccination.
Seropositivity remained at or above 94.6% for type 1, 98.2% for type 2, and 91.1% for type 3 for at least 6 years after four OPV doses, with almost identical rates in children 1 to 2 years after five doses.
Humoral immunity to poliovirus types 3 and 1 declined significantly at 9 and 17 years after the booster dose, respectively, whereas type 2 immunity remained stable across the entire 19-year period.
Geometric mean titers were consistently higher for types 1 and 2 than type 3, accounting for type 3 titers dropping below detection limits at later time points.

Structured PICO

Does the oral polio vaccine (OPV) provide long-lasting poliovirus-neutralizing antibodies in an immunized population?

Population

297 individuals residing in Argentina who had completed the vaccination cycle with four or five oral polio vaccine (OPV) doses 1 month to 19 years before the study

Intervention

Four or five oral polio vaccine (OPV) doses

Outcome

Persistence of poliovirus-neutralizing antibodies (seropositivity for polio types 1, 2, and 3)surrogate

Oral polio vaccine induces remarkably long-lived neutralizing antibodies, though immunity to types 1 and 3 declines significantly at 17 and 9 years post-booster, respectively.

Cite This Study

Nates et al. (2007) studied this question.

synapsesocial.com/papers/6a8bfa17b676b7d1a2fb8a9e https://doi.org/10.1089/vim.2006.0071

View Full Paper

Ask AI

Bookmark

Long-Lasting Poliovirus-Neutralizing Antibodies among Argentinean Population Immunized with Four Or Five Oral Polio Vaccine Doses 1 Month to 19 Years Previously

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Long-Lasting Poliovirus-Neutralizing Antibodies among Argentinean Population Immunized with Four Or Five Oral Polio Vaccine Doses 1 Month to 19 Years Previously

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider