Why the study?
Does a full vaccination course with live attenuated poliovirus maintain protective neutralizing antibody titres 2-16 years post-immunization in children and young adults?
Population
1,155 subjects from the mainland of Venice, Italy, who had received a full vaccination course with live…
Design
Cohort
Follow-up
2-16 years
Authors
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Declining poliovirus 3 titres may signal immunity gaps in young adults; hypothesis-generating for serosurveillance and booster strategies.
Does a full vaccination course with live attenuated poliovirus maintain protective neutralizing antibody titres 2-16 years post-immunization in children and young adults?
Vaccine-induced humoral immunity against poliovirus, especially strain 3, declines substantially over 16 years, highlighting a potential gap in herd immunity among young adults.
Trivello et al. (1988) studied this question.
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