Key result
Recently-immunized children had significantly higher geometric mean titers of neutralizing antibodies for all three poliovirus serotypes compared to unvaccinated elderly individuals (p < 0.001), though both groups demonstrated valid immunity.
Population
511 healthy subjects resident in the Veneto Region, Italy, comprising 231 children/adolescents aged 1-17…
Design
Cross-sectional
Authors
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Supports current polio immunity strategies in Italy; leaves open durability of protection by age and immunization type.
Cross-Sectional (n=511)
No
Absolute Event Rate: 252.2% vs 65.8%
p-value: p=<0.001
Both recently vaccinated children and naturally immunized elderly populations in north-east Italy maintain valid immunity to poliovirus, supporting current public health strategies.
Majori et al. (2015) conducted a cross-sectional in Poliovirus immunity (n=511). OPV vaccination vs. Unvaccinated elderly was evaluated on Geometric mean titers (GMTs) of neutralizing antibodies for poliovirus type 1 (p=<0.001). Recently-immunized children had significantly higher geometric mean titers of neutralizing antibodies for all three poliovirus serotypes compared to unvaccinated elderly individuals (p < 0.001), though both groups demonstrated valid immunity.
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