Key result
The pooled prevalence of Italian subjects without poliovirus neutralizing antibodies was 6.4% for PV1, 5.3% for PV2, and 13.0% for PV3, with immunity waning as time since the last vaccine dose increased.
Why the study?
Evaluating susceptible individuals through seroepidemiological studies is needed to ensure high immunization coverage in low-endemicity countries where sporadic polio cases can occur.
Design
Systematic review and meta-analysis
Authors
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May warrant PV3 boosters to sustain polio-free status; confirms high seroprevalence to PV1/2.
Meta-Analysis (n=3,310)
Effect estimate: 6.4% pooled prevalence (95% CI 0.5-16.9)
The Italian population maintains high levels of neutralizing antibodies against poliovirus types 1 and 2, with slightly lower immunity against type 3, supporting the need for booster doses to maintain polio-free status.
Tafuri et al. (2023) conducted a meta-analysis in Poliovirus susceptibility (n=3,310). Poliovirus vaccination was evaluated on Pooled prevalence of subjects without PV1 neutralizing antibodies (6.4% pooled prevalence, 95% CI 0.5-16.9). The pooled prevalence of Italian subjects without poliovirus neutralizing antibodies was 6.4% for PV1, 5.3% for PV2, and 13.0% for PV3, with immunity waning as time since the last vaccine dose increased.
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