Key result
Trivalent oral polio vaccine stimulates intestinal secretory IgA formation, which provides local immunity to prevent viral replication and inhibit poliovirus transmission.
Key points are not available for this paper at this time.
May inform polio vaccine strategies via mucosal effects; leaves open confirmation in higher-level trials.
The trivalent oral polio vaccine (tOPV) produced by Bio Farma consists of three live, attenuated poliovirus serotypes (1, 2, and 3). The tOPV stimulates the formation of secretory IgA (sIgA) on the intestinal wall and lumen. The existence of sIgA is considered giving immunity in the intestines, it could prevent the spread of viral replication and thus inhibit the transmission of the polio virus.
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Rusmil et al. (2015) studied this question. Trivalent oral polio vaccine stimulates intestinal secretory IgA formation, which provides local immunity to prevent viral replication and inhibit poliovirus transmission.
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