Key result
The quantity of vaccine poliovirus shedding 7 days after oral poliovirus vaccine administration correlated with the magnitude of the serum neutralizing antibody response at 21 or 28 days.
Why the study?
Does the quantity of vaccine poliovirus shed determine the titer of the serum neutralizing antibody response in children receiving oral poliovirus vaccine?
Observational (n=518)
Does the quantity of vaccine poliovirus shed determine the titer of the serum neutralizing antibody response in children receiving oral poliovirus vaccine?
The immune response to oral poliovirus vaccine is on a continuum dependent on efficient vaccine virus replication, as demonstrated by the correlation between viral shedding and neutralizing antibody titers.
OPV shedding quantity may indicate antibody response magnitude in children; supports replication efficiency driving immunogenicity but leaves causal effects open for trials.
Replication of oral poliovirus vaccine (OPV) in the intestine (ie, vaccine take) is associated with seroconversion and protection against poliomyelitis. We used quantitative polymerase chain reaction analysis to measure vaccine shedding in 300 seronegative infants aged 6-11 months and in 218 children aged 1-4 years 7 days after administration of monovalent or bivalent OPV. We found that the quantity of shedding correlated with the magnitude of the serum neutralizing antibody response measured 21 or 28 days after vaccination. This suggests that the immune response to OPV is on a continuum, rather than an all-or-nothing phenomenon, that depends on efficient vaccine virus replication.
No takes yet. Share an insight, caveat, or question.
Giri et al. (2017) conducted an observational in Poliomyelitis vaccination (n=518). Quantity of vaccine poliovirus shedding was evaluated on Magnitude of the serum neutralizing antibody response. The quantity of vaccine poliovirus shedding 7 days after oral poliovirus vaccine administration correlated with the magnitude of the serum neutralizing antibody response at 21 or 28 days.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: