Key result
A second dose of trivalent poliovirus vaccine increased seroconversion for types I, II, and III from 87% to 97%, 43% to 69%, and 91% to 100%, respectively.
Why the study?
Does a second dose of trivalent poliovirus vaccine or contact transmission improve seroconversion rates in children?
Does a second dose of trivalent poliovirus vaccine or contact transmission improve seroconversion rates in children?
A second dose of trivalent poliovirus vaccine significantly increases seroconversion rates, and contact transmission also contributes to seroconversion in unvaccinated children.
May support second-dose polio vaccination to boost seroconversion; leaves open optimal regimens and contact transmission effects.
Two groups of children received trivalent poliovirus vaccine. Group B had two doses, 10 to 11 weeks apart. Group A had one dose after 10 to 11 weeks of contact with Group B vaccinates. The second dose increased Group B seroconversions for poliovirus types I, II, and III, respectively, from 87% to 97%, 43% to 69%, and 91% to 100%. Corresponding Group A seroconversions resulting from contact were 25%, 20%, and 52% and increased following a single dose of vaccine to 99%, 60%, and 100%. Children with seven different wild enterovirus infections responded to vaccine type I. Rates of type I shedding after vaccination of children already type I seropositive were approximately 18% for those under 7 years of age and 60% for those under 2 years of age.
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Roca-Garcia et al. (1964) studied Poliovirus infection prevention. Trivalent poliovirus vaccine vs. Single dose or contact exposure was evaluated on Seroconversion for poliovirus types I, II, and III. A second dose of trivalent poliovirus vaccine increased seroconversion for types I, II, and III from 87% to 97%, 43% to 69%, and 91% to 100%, respectively.
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