Population
Cells infected with a temperature-sensitive strain of type 1 poliovirus (LSc)
Comparison
Incubation at 40 C in the presence of Mahoney, a… vs Permissive conditions or absence of Mahoney strain
Design
Preclinical
Authors
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Functional rescue of ts poliovirus shown in models; leaves open relevance to human infection or vaccine development.
A temperature-sensitive strain of type 1 poliovirus can be functionally rescued by a temperature-resistant strain at non-permissive temperatures.
Nichol et al. (1968) studied this question.
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