March 1, 1969Journal of VirologyOpen Access

Synthesis of Ribonucleic Acid in Cells Infected with LSc Poliovirus at Elevated Temperatures

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Population

Cells infected with LSc poliovirus

Comparison

Elevated temperatures and/or p-fluorophenylalanine vs Control temperature and/or control virus

Design

Preclinical

Follow-up

Up to 3.5 hours after infection

Authors

DTDaniel R. TershakPennsylvania State University

Discussion

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Implication

Temperature-sensitive and capsid-selective inhibition of poliovirus replication remains hypothesis-generating; leaves open translation to in vivo or clinical antiviral strategies.

Structured PICO

Population

Cells infected with LSc poliovirus

Intervention

Elevated temperatures (39 to 40 C) and/or p-fluorophenylalanine (10-25 mug/ml)

Comparator

Control temperature (35 C) and/or control virus (no analogue)

Outcome

Synthesis of viral RNA and production of infectious virussurrogate

Elevated temperatures inhibit late-stage viral RNA synthesis in LSc poliovirus-infected cells, while p-fluorophenylalanine selectively affects viral capsid protein without reversing the temperature-induced RNA synthesis inhibition.

Cite This Study

Daniel R. Tershak (1969) studied this question.

synapsesocial.com/papers/6a867394bc4cc88ab58341de https://doi.org/10.1128/jvi.3.3.297-303.1969

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Implication

Temperature-sensitive and capsid-selective inhibition of poliovirus replication remains hypothesis-generating; leaves open translation to in vivo or clinical antiviral strategies.

Synthesis of Ribonucleic Acid in Cells Infected with LSc Poliovirus at Elevated Temperatures

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Synthesis of Ribonucleic Acid in Cells Infected with LSc Poliovirus at Elevated Temperatures

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider