Breakdown of RNA alone is unlikely to explain the temperature sensitivity of attenuated polioviruses.
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RNA degradation alone unlikely explains attenuated poliovirus temperature sensitivity; leaves open alternative mechanisms for study.
From 15 to 20% of the RNA of virulent strains of poliovirus is degraded at 35 °C several hours after maximal synthesis is reached. From 20 to 30% of the RNA of attenuated viruses is degraded under the same conditions. Cultures placed at 40 °C in the presence of 3 mM guanidine during the linear stage of RNA synthesis lead to breakdown of 15 to 40% of the RNA of virulent viruses and 30 to 40% of the RNA of attenuated viruses. It is doubtful that breakdown of RNA alone can explain the temperature sensitivity of attenuated viruses.
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Adler et al. (1973) studied this question.
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