October 1, 1994Journal of VirologyOpen Access

Thermal inactivation of oral polio vaccine: contribution of RNA and protein inactivation

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Population

Sabin strains of poliovirus

Comparison

Heating at 42 to 45 degrees C with pirodavir vs Heating at 42 to 45 degrees C without pirodavir

Design

Preclinical

Authors

Discussion

Pirodavir may stabilize poliovirus capsids against heat; leaves open translation to vaccine stability or antiviral use pending in vivo studies.

Population

Sabin strains of poliovirus

Intervention

Heating at 42 to 45 degrees C with pirodavir

Comparator

Heating at 42 to 45 degrees C without pirodavir

Outcome

Viral inactivation, loss of native antigen, and release of viral RNA

Thermoinactivation of poliovirus involves both RNA and protein components, with pirodavir protecting specifically against the protein component.

Rombaut et al. (1994) studied this question.

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Pirodavir may stabilize poliovirus capsids against heat; leaves open translation to vaccine stability or antiviral use pending in vivo studies.