Population
Oral poliovaccine strains
Comparison
Reducing the pH below 7 vs Standard conditions or addition of salts such as…
Design
Preclinical
Authors
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May support pH-adjusted oral poliovaccine testing for heat stability; leaves open translation from animal data to clinical use.
Reducing the pH below 7 stabilizes oral poliovaccine at high ambient temperatures by inhibiting RNA polymerase activity.
Newman et al. (1995) studied this question.
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