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Discusses potential technologies, such as antiviral components and novel drying methods, to improve the thermostability of the oral poliovirus vaccine.
Technologies that promise to enhance the stability of vaccines are likely to be determined by the product-specific physical structure and biological functions of the specific vaccine immunogens. Research may define the extent to which the stability of oral poliovirus vaccine may be improved by the addition of certain antiviral components that bind to the poliovirus capsid or by the application of novel drying technologies.
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Lemon et al. (1994) studied this question.
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