Population
Oral poliovirus vaccines (all 3 types)
Comparison
M MgCl2 stabilization at pH 6.4 in tightly… vs Ordinary thermolabile vaccine
Design
Preclinical
Follow-up
Up to 18 months at 4°C, 3 weeks at 25-28°C
Authors
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May support expanded polio vaccine access in low-resource settings; leaves open human translation and efficacy trials.
MgCl2 stabilization at pH 6.4 significantly improves the thermal stability of oral poliovirus vaccines, eliminating limitations of thermolabile vaccines.
Melnick et al. (1963) studied this question.
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