May 1, 1994Journal of VirologyOpen Access

Discrepancy between infectivity and antigenicity stabilization of oral poliovirus vaccine by a capsid-binding compound

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Population

Oral poliovirus vaccine strains (Sabin type 2 and type 3)

Comparison

Pyridazinamine derivatives vs Absence of R 77975, or 1 M MgCl2

Design

Preclinical

Authors

Discussion

May inform thermostable OPV development; leaves open translation from animal data to clinical use.

Population

Oral poliovirus vaccine strains (Sabin type 2 and type 3)

Intervention

Pyridazinamine derivatives (specifically R 77975 / pirodavir)

Comparator

Absence of R 77975, or 1 M MgCl2

Outcome

Stabilization of antigenicity and infectivity under heat stresssurrogate

The capsid-binding compound R 77975 preserves the N antigenicity of oral poliovirus vaccine even when infectivity is lost due to heat stress.

Andries et al. (1994) studied this question.

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