Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 1972Journal of VirologyOpen Access

Thermosensitive Block of the Sabin Strain of Poliovirus Type I

View Full Paper
Ask AI
Bookmark
Share

Population

KB cells infected with Sabin LSc2ab strain of poliovirus type I

Comparison

Transfer from 36 C to 38.5 C vs Maintained at 36 C (permissive temperature)

Design

Preclinical

Authors

MFMarc FiszmanUniversité Claude Bernard Lyon 1MRM ReynierEurofins (France)DBDanielle BucchiniInstitut Pasteur

Discussion

Loading...

Member takes

Implication

May inform live poliovirus vaccine attenuation strategies; leaves open applicability to other enteroviruses.

Structured PICO

P
Population
KB cells infected with Sabin LSc2ab strain of poliovirus type I
I
Intervention
Transfer from 36 C to 38.5 C (non-permissive temperature)
C
Comparator
Maintained at 36 C (permissive temperature)
O
Outcome
Viral RNA replication and formation of virionssurrogate

The thermosensitive defect in the Sabin strain of poliovirus type I lies in the assembly of viral capsid proteins into capsomeres at non-permissive temperatures.

Cite This Study

Fiszman et al. (1972) studied this question.

synapsesocial.com/papers/6a902401779e50c2dc90a129https://doi.org/10.1128/jvi.10.6.1143-1151.1972
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.1965 · 362 citations
  2. 2Inhibition of Poliovirus RNA Synthesis by Supraoptimal Temperatures1970 · 22 citations
  3. 3Synthesis of Ribonucleic Acid in Cells Infected with LSc Poliovirus at Elevated Temperatures1969 · 13 citations
  4. 4Purification of the Sabin Strain of Poliovirus Type I Through Treatment with Sarkozyl1971 · 10 citations
  5. 5Polypeptide cleavages in the formation of poliovirus proteins.1968 · 351 citations