Key result
Persistent poliovirus infection in human neuroblastoma cells correlated with the selection of highly mutated viral strains, with persistent viruses showing 1-3 log10 units higher titers on IMR-32 cells.
Population
Two human neuroblastoma cell lines (IMR-32 cells studied in greatest detail)
Comparison
Persistent infection with poliovirus strains of… vs Nonneuronal HEp-2 cells and parental viruses
Design
Preclinical
Follow-up
9 months
Authors
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Provides in vitro model for poliovirus persistence; leaves open in vivo relevance to human neurological disease.
Poliovirus-infected neuroblastoma cell lines can serve as an in vitro model of chronic viral infections, demonstrating that persistent infection correlates with the selection of highly mutated viral strains.
Colbère-Garapin et al. (1989) studied Poliovirus infection. Persistent poliovirus infection vs. Parental viruses / nonneuronal HEp-2 cells was evaluated on Viral characteristics (antigenic site modification, host cell specificity, temperature resistance). Persistent poliovirus infection in human neuroblastoma cells correlated with the selection of highly mutated viral strains, with persistent viruses showing 1-3 log10 units higher titers on IMR-32 cells.
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