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September 1, 1989Journal of VirologyOpen Access

Restricted growth of attenuated poliovirus strains in cultured cells of a human neuroblastoma

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Population

Cultured cells of a human neuroblastoma, SK-N-MC

Comparison

Infection with Sabin attenuated poliovirus types… vs Infection with related neurovirulent strains of…

Design

Preclinical

Authors

VAVadim I. AgolLomonosov Moscow State UniversitySDS. G. DrozdovRussian Academy of SciencesTIT A IvannikovaLomonosov Moscow State University

Discussion

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Implication

SK-N-MC cells may model poliovirus neurovirulence in vitro; leaves open in vivo validation before research adoption.

Structured PICO

P
Population
Cultured cells of a human neuroblastoma, SK-N-MC
I
Intervention
Infection with Sabin attenuated poliovirus types 1 and 2 strains and intratypic (type 1) poliovirus recombinants
C
Comparator
Infection with related neurovirulent strains of poliovirus
O
Outcome
Viral growth and yield (cytopathic effect and total harvest)surrogate

Human neuroblastoma SK-N-MC cells restrict the growth of attenuated poliovirus strains compared to neurovirulent strains, suggesting their potential as an in vitro model for studying poliovirus neurovirulence.

Cite This Study

Agol et al. (1989) studied this question.

synapsesocial.com/papers/6a792fef8a3ae1c742320af2https://doi.org/10.1128/jvi.63.9.4034-4038.1989
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Also Consider

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  1. 1IN VITRO DIFFERENTIATION OF VIRULENT AND ATTENUATED POLIOVIRUSES BY THEIR GROWTH CHARACTERISTICS ON MS CELLS1959 · 84 citations
  2. 2Attachment, Uncoating and Blockage of Cell Protein Synthesis by Sabin Derivatives of Poliovirus in HeLa and Vero Cells1988 · 3 citations
  3. 3Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.1982 · 310 citations
  4. 4Translational efficiency of poliovirus mRNA: mapping inhibitory cis-acting elements within the 5' noncoding region1988 · 67 citations
  5. 5Oral Poliovirus Vaccine: History of Its Development and Use and Current Challenge to Eliminate Poliomyelitis from the World1985 · 286 citations