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May 1, 1986Journal of VirologyOpen Access

Genetic analysis of the attenuation phenotype of poliovirus type 1

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Population

Recombinant viruses from virulent Mahoney and attenuated Sabin parental strains of type 1 poliovirus, tested…

Comparison

Recombinant viruses with different genomic loci vs Parental strains (Mahoney and Sabin)

Design

Preclinical

Authors

TOT OmataTokyo Metropolitan Institute of Medical ScienceMKMichinori KoharaTokyo Metropolitan Institute of Medical ScienceSKShusuke KugeTohoku Medical and Pharmaceutical University

Discussion

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Implication

Multiple genomic loci determine Sabin 1 attenuation in models; leaves open whether single in vitro markers predict neurovirulence.

Structured PICO

P
Population
Recombinant viruses from virulent Mahoney and attenuated Sabin parental strains of type 1 poliovirus, tested in monkeys
I
Intervention
Recombinant viruses with different genomic loci
C
Comparator
Parental strains (Mahoney and Sabin)
O
Outcome
Neurovirulence (lesion score, spread value, and incidence of paralysis) and in vitro phenotypic markerssurrogate

The attenuated phenotype of the Sabin 1 strain of poliovirus is the result of several different biological characteristics spread across the viral genome.

Cite This Study

Omata et al. (1986) studied this question.

synapsesocial.com/papers/6a71f28e2163a0a01bc5dcddhttps://doi.org/10.1128/jvi.58.2.348-358.1986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vitro phenotypic markers of a poliovirus recombinant constructed from infectious cDNA clones of the neurovirulent Mahoney strain and the attenuated Sabin 1 strain1985 · 64 citations
  2. 2Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.1982 · 310 citations
  3. 3Reversion to neurovirulence of the live-attenuated Sabin type 3 oral pollovirus vaccine1984 · 149 citations
  4. 4Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies1982 · 137 citations
  5. 5Live Attenuated Oral Poliovirus Vaccine1984 · 19 citations