Population
Poliovirus type 1 (Mahoney and Sabin 1 strains) and monkey models for neurovirulence tests
Comparison
Introduction of deletions into the 5' noncoding… vs Corresponding parental viruses
Design
Preclinical
Authors
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Animal data support testing attenuated poliovirus strains as vaccine candidates; human safety and efficacy remain unproven.
Introducing deletions into the 5' noncoding sequence of poliovirus genomes creates stable, less neurovirulent strains, which may be useful for vaccine development.
Iizuka et al. (1989) studied this question.
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