Identifies specific point mutations in poliovirus RNA responsible for the attenuated phenotype of Sabin vaccine strains.
Polioviruses of reduced neurovirulence contain point mutations in the viral RNA that are responsible for the attenuated phenotype. Two such point mutations have been identified in the genomes of the Sabin live oral vaccine strains, one in the 5′‐noncoding region of the viral RNA, and one in capsid polypeptide VP3.
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Vincent R. Racaniello (1986) studied this question.
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