Identified a consistent pattern of mutations common to neurovirulent variants of poliovirus type 2 derived from the Sabin vaccine strain.
Warrants inclusion of VP1-143 in poliovirus genomic surveillance; leaves open causal role in human neurovirulence.
Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2 712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants of poliovirus type 2.
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Equestre et al. (1991) studied this question.
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