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Identified 23 point mutations that differentiate a neurovirulent type 2 poliovirus strain from the Sabin vaccine strain, providing insight into the evolution of neurovirulence.
Infectious cDNAs of the Sabin type 2 poliovirus vaccine virus and a vaccine-derived neurovirulent type 2 strain (P2/117) have been cloned in Escherichia coli. Nucleotide sequence analysis revealed that P2/117 differs from the vaccine strain by just 23 point mutations. Three occur in the 5' noncoding region. The remainder result in a total of 5 coding changes located in VP1, VP4, 2B, and 3D. The likely role of these mutations in the evolution to neurovirulence is discussed.
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Pollard et al. (1989) studied this question.
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