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January 1, 1984Nucleic Acids ResearchOpen Access

Reversion to neurovirulence of the live-attenuated Sabin type 3 oral pollovirus vaccine

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Population

Poliovirus type 3 strain P3/119 isolated from the central nervous system of a victim of fatal…

Comparison

Nucleotide sequencing and comparison vs Sabin type 3 vaccine and its neurovirulent…

Design

Preclinical

Authors

ACAlan J. CannInstitute of Cancer ResearchGSGlyn StanwayUniversity of EssexPHPamela HughesUniversity of Minnesota

Discussion

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Implication

Identifies reversion mutations in Sabin type 3; leaves open their contribution to human neurovirulence.

Structured PICO

P
Population
Poliovirus type 3 strain P3/119 isolated from the central nervous system of a victim of fatal vaccine-associated poliomyelitis
I
Intervention
Nucleotide sequencing and comparison
C
Comparator
Sabin type 3 vaccine (P3/Leon 12a1b) and its neurovirulent progenitor (P3/Leon/37)
O
Outcome
Nucleotide sequence differencessurrogate

The Sabin type 3 oral poliovirus vaccine can revert to neurovirulence through specific nucleotide mutations, including a key back mutation in the noncoding region.

Cite This Study

Cann et al. (1984) studied this question.

synapsesocial.com/papers/6a705fc5a2d7cf2e39c2a7b9https://doi.org/10.1093/nar/12.20.7787
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of the complete nucleotide sequences of the genomes of the neurovirulent poliovirus P3/Leon/37 and its attenuated Sabin vaccine derivative P3/Leon 12a1b.1984 · 189 citations
  2. 2Nucleic acid sequence of the region of the genome encoding capsid protein VP1 of neurovirulent and attenuated type 3 polioviruses1983 · 12 citations
  3. 3The nucleotide sequence of poliovirus type 3 leon 12 a<sup>1</sup>b: comparison with poliovirus type 11983 · 142 citations
  4. 4Characterization of Strains of Type 3 Poliovirus by Oligonucleotide Mapping1982 · 48 citations
  5. 5Evolution of poliovirus since introduction of attenuated vaccine.1977 · 33 citations