Population
Vero cells and monkeys (preclinical model)
Comparison
cDNA-derived virus representing the vaccine… vs Derivative virus possessing a single base change…
Design
Preclinical
Authors
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No immediate change to polio vaccination; supports 2493 role in Sabin 3 attenuation but remains hypothesis-generating.
The mutation at position 2493 in the Sabin 3 poliovirus VP1 protein contributes to the attenuated phenotype of the vaccine strain.
Tatem et al. (1992) studied this question.
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