August 1, 1993Journal of VirologyOpen Access

A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice

View Full Paper

Ask AI

Bookmark

Population

Mouse model inoculated with mouse-adapted PV-1/PV-2 chimeric strain v510 and hybrid v510/Sabin 1

Comparison

Mutagenesis of locus 6203 in the 3D polymerase… vs Original v510 strain and hybrid v510/Sabin 1…

Design

Preclinical

Authors

MTM Tardy-PanitInstitut Pasteur BBB BlondelInserm AMAnnette MartinCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Extends attenuation genetics in a mouse model; leaves open human vaccine relevance and requires further validation.

Structured PICO

Population

Mouse model inoculated with mouse-adapted PV-1/PV-2 chimeric strain v510 (a Mahoney strain carrying nine amino acids of the VP1 capsid protein from the Lansing strain of PV-2) and hybrid v510/Sabin 1

Intervention

Mutagenesis of locus 6203 (U-6203-->C and C-6203-->U) in the 3D polymerase gene

Comparator

Original v510 strain and hybrid v510/Sabin 1 without the specific mutagenesis

Outcome

Disease incidence and time to disease onsetsurrogate

The C-6203 mutation in the 3D polymerase gene of poliovirus type 1 contributes to viral attenuation and thermosensitivity in a mouse model.

Cite This Study

Tardy-Panit et al. (1993) studied this question.

synapsesocial.com/papers/6a6f9d9e75498292b708fe19 https://doi.org/10.1128/jvi.67.8.4630-4638.1993

View Full Paper

Ask AI

Bookmark

A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider