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October 1, 1983European Journal of BiochemistryOpen Access

Nucleic acid sequence of the region of the genome encoding capsid protein VP1 of neurovirulent and attenuated type 3 polioviruses

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Population

Three closely related strains of poliovirus type 3 (neurovirulent and attenuated)

Design

Preclinical

Authors

GSGlyn StanwayUniversity of EssexACAlan J. CannInstitute of Cancer ResearchRHR HauptmannBoehringer Ingelheim (Austria)

Discussion

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Implication

Excludes VP1 as the attenuating locus in type 3 Sabin virus; leaves open other genomic sites for mapping in vaccine research.

Structured PICO

P
Population
Three closely related strains of poliovirus type 3 (neurovirulent and attenuated)
I
Intervention
Molecular cloning via an RNA-cDNA method and comparative nucleotide sequencing of the region encoding VP1
O
Outcome
Structural differences in the VP1 region between neurovirulent and attenuated type 3 strains

The molecular basis of attenuation of type 3 Sabin vaccine virus does not involve the VP1 polypeptide, unlike type 1 poliovirus.

Cite This Study

Stanway et al. (1983) studied this question.

synapsesocial.com/papers/6a845f17121b098de683eb35https://doi.org/10.1111/j.1432-1033.1983.tb07684.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DNA sequencing with chain-terminating inhibitors1977 · 69,520 citations
  2. 2A mew computer method for the storage and manipulation of DNA gel reading data1980 · 688 citations
  3. 3Oligonucleotide mapping: evaluation of its sensitivity by computer-simulation1982 · 71 citations