Population
Mouse model for poliomyelitis
Comparison
Recombinants between avirulent poliovirus strain… vs P2/Lansing strain and P2/P712 strain
Design
Preclinical
Authors
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Confirms Sabin-like attenuation in type 2 poliovirus; extends prior type 1/3 mapping from animal data.
The attenuated poliovirus type 2 strain P712 contains multiple attenuating sequences, including strongly attenuating sequences in the 5' noncoding region, similar to type 1 and type 3 Sabin vaccine strains.
Moss et al. (1989) studied this question.
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