January 1, 1990Journal of General Virology

Localization of Genomic Regions Specific for the Attenuated, Mouse-adapted Poliovirus Type 2 Strain W-2

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Population

Poliovirus type 2 strains

Design

Preclinical

Authors

DPDaniel C. PevearVenatoRx Pharmaceuticals (United States)COChang Kyu OhChung-Ang University LCLisa L. CunninghamNational Institute on Deafness and Other Communication Disorders

Discussion

Member takes

Implication

Hypothesis-generating for PV2 attenuation mechanisms in animals; leaves open relevance to human vaccine strategies.

Structured PICO

Population

Poliovirus type 2 strains (attenuated mouse-adapted W-2, virulent mouse-adapted Lansing, and non-mouse-adapted attenuated Sabin)

Intervention

Genomic sequencing and computer-generated sequence comparison

Outcome

Genomic sequence differences and mutational patternssurrogate

Genomic comparison of poliovirus type 2 strains identifies specific mutations in neutralization sites and the polymerase region that may contribute to viral attenuation.

Cite This Study

Pevear et al. (1990) studied this question.

synapsesocial.com/papers/6a8af45b95f0361a9ebea44e https://doi.org/10.1099/0022-1317-71-1-43

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Localization of Genomic Regions Specific for the Attenuated, Mouse-adapted Poliovirus Type 2 Strain W-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Localization of Genomic Regions Specific for the Attenuated, Mouse-adapted Poliovirus Type 2 Strain W-2

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider