Population
Mice and in vitro viral models (Poliovirus type 1 strain LS-a and PV1(Mahoney))
Comparison
In vitro mutagenesis and chimeric cDNA… vs Mouse avirulent progenitor PV1(Mahoney)
Design
Preclinical
Authors
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May guide poliovirus attenuation strategies in mice; hypothesis-generating and should not inform human vaccines or therapies.
Mouse neurovirulence of poliovirus type 1 strain LS-a is determined by mutations in the viral proteinase 2Apro and capsid protein VP1, which also affect capsid stability.
Lu et al. (1994) studied this question.
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