Foot-and-mouth disease virus can develop thermal resistance under heat selection, but partially reverts when the selection pressure is removed.
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Thermal selection may enrich resistant FMDV particles; hypothesis-generating for vaccine stability and requires mammalian validation.
SummaryA small thermal-resistant fraction (10−3 to 10−5 at 55°C) of foot-and-mouth disease virus, type A, has been isolated from a wild population. Under continuing thermal selection, it breeds populations which contain much higher fractions, at least 10−1, of thermal-resistant virus particles. Such populations revert partially, however, toward the sensitivity of the wild strain if not subjected to heat.
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Bachrach et al. (1960) studied this question.
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