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January 1, 1970Journal of General Virology

Identification of Poliovirus Temperature-sensitive Mutants having Defects in Virus Structural Protein

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Population

29 temperature-sensitive (ts) mutants of poliovirus

Comparison

In vitro testing at 45°C vs ts+ poliovirus

Design

Preclinical

Authors

DMD. McCahonThe Pirbright InstitutePCPaul D. CooperAustralian National University

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Implication

Extends poliovirus structural gene mapping in animal models; leaves open translation to human vaccines or pathogenesis.

Structured PICO

P
Population
29 temperature-sensitive (ts) mutants of poliovirus
I
Intervention
In vitro testing at 45°C
C
Comparator
ts+ poliovirus
O
Outcome
Loss of infectivity (thermolability) and structural protein defects

The study maps the genetic region specifying poliovirus structural proteins by identifying temperature-sensitive mutants with thermolabile structural defects.

Cite This Study

McCahon et al. (1970) studied this question.

synapsesocial.com/papers/6a6ff37bfebe604dd708c47ehttps://doi.org/10.1099/0022-1317-6-1-51
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Production of Infectious RNA and Serum-blocking Antigen by Poliovirus Temperature-sensitive Mutants1968 · 16 citations