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March 1, 1968Journal of General Virology

Production of Infectious RNA and Serum-blocking Antigen by Poliovirus Temperature-sensitive Mutants

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Population

Poliovirus temperature-sensitive (ts) mutants and parental ts+ strain

Comparison

Cultivation at 39.6°C vs Parental ts+ strain cultivated at the same…

Design

Preclinical

Authors

BWBerttina B. WentworthWayne State UniversityDMD. McCahonThe Pirbright InstitutePCPeter D. CooperUniversity of Virginia

Discussion

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Overview

Groups poliovirus ts mutants by productivity gradient; leaves open molecular drivers of maturation defects in model systems.

Structured PICO

P
Population
Poliovirus temperature-sensitive (ts) mutants and parental ts+ strain
I
Intervention
Cultivation at 39.6°C
C
Comparator
Parental ts+ strain cultivated at the same temperature
O
Outcome
Production of infectious RNA and serum-blocking antigensurrogate

Poliovirus ts mutants show a gradient of RNA and antigen productivity at non-permissive temperatures, correlating with physiological classifications and revealing defects in maturation or assembly for specific groups.

Cite This Study

Wentworth et al. (1968) studied this question.

synapsesocial.com/papers/6a6ff37bfebe604dd708c47fhttps://doi.org/10.1099/0022-1317-2-2-297
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