Coinfection of cattle with distinct FMDV serotypes can lead to the emergence of novel recombinant strains in the upper respiratory tract.
May guide FMD surveillance in livestock; leaves open confirmation of recombinant transmission in natural settings.
FMDV coinfections under controlled experimental conditions. Our findings confirmed that cattle could be simultaneously infected by two distinct serotypes of FMDV, with different outcomes associated with the timing of exposure to the two different viruses. Additionally, dominant interserotypic recombinant FMDVs were discovered in multiple samples from the upper respiratory tracts of five superinfected animals, emphasizing the potential importance of persistently infected FMDV carriers as sources of novel FMDV strains.
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Arzt et al. (2021) studied this question.
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