Why the study?
Extensive viral population diversity and continuous mutation of foot-and-mouth disease viruses pose significant obstacles to control and eradication, prompting investigation into within-host evolutionary mechanisms in cattle.
Population
Vaccinated and non-vaccinated cattle
Comparison
Vaccinated vs non-vaccinated cattle infected with FMDV
Design
Controlled experimental infection study
Follow-up
Up to 35 days
Authors
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May indicate host factors predominate in FMDV persistence; hypothesis-generating for carrier-state mechanisms in livestock.
The establishment of the FMDV carrier state in cattle is not associated with specific viral genomic characteristics, but rather driven by pre-existing haplogroups and point mutations.
Arzt et al. (2019) studied this question.
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