Key result
Vaccination induced significant differences in FMDV substitution rates, entropy, and adaptation compared to non-vaccinated cattle during experimental infection.
Why the study?
The behavior of the foot-and-mouth disease virus quasispecies had not been described in detail in natural host species.
Does vaccination alter the viral population dynamics and adaptation of FMDV in cattle?
Population
Vaccinated and non-vaccinated cattle experimentally infected with FMDV A24-Cruzeiro
Comparison
Vaccinated vs non-vaccinated cattle
Design
Experimental infection study with deep-sequencing analysis
Follow-up
Up to 35 days post-infection
Authors
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May alter FMDV quasispecies in vaccinated cattle; hypothesis-generating and should not yet change vaccination practices.
Does vaccination alter the viral population dynamics and adaptation of FMDV in cattle?
Vaccination against FMDV in cattle significantly alters the viral quasispecies dynamics, inducing early bottlenecks and delayed antigenic escape mutations.
Fish et al. (2020) studied Foot-and-mouth disease virus (FMDV) infection. Vaccination vs. Non-vaccinated cattle was evaluated on Viral substitution rates, entropy, and evidence for adaptation. Vaccination induced significant differences in FMDV substitution rates, entropy, and adaptation compared to non-vaccinated cattle during experimental infection.
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